Retinol-d8

Names

[ CAS No. ]:
212848-81-2

[ Name ]:
Retinol-d8

Biological Activity

[Description]:

Retinol-d8 is the deuterium labeled Vitamin A. Retinol is an endogenous metabolite.

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Zhang M, et al. High-fat diet enhanced retinal dehydrogenase activity, but suppressed retinol dehydrogenase activity in liver of rats. J Pharmacol Sci. 2015 Apr;127(4):430-8.;Miyazaki H, et al. Retinol status and expression of retinol-related proteins in

Chemical & Physical Properties

[ Molecular Formula ]:
C20H22D8O

[ Molecular Weight ]:
294.50

Related Compounds