NSC 8751-d6

Names

[ CAS No. ]:
21386-86-7

[ Name ]:
NSC 8751-d6

Biological Activity

[Description]:

NSC 8751-d6 is the deuterium labeled NSC 8751[1]. NSC 8751 is an endogenous metabolite[2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Fausto R, et al. UV-induced isomerization of (E)-crotonic acid. Combined matrix-isolated IR and ab initio MO study[J]. Journal of the Chemical Society, Faraday Transactions, 1995, 91(21): 3755-3770.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

Chemical & Physical Properties

[ Molecular Formula ]:
C5H2D6O2

[ Molecular Weight ]:
106.15

Related Compounds