Amidate-VC-PAB-MMAF

Names

[ CAS No. ]:
2202782-90-7

[ Name ]:
Amidate-VC-PAB-MMAF

Biological Activity

[Description]:

Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Nareshkumar Jain, et al. Current ADC Linker Chemistry. Pharm Res. 2015 Nov;32(11):3526-40.

Chemical & Physical Properties

[ Molecular Formula ]:
C69H102N11O16P

[ Molecular Weight ]:
1372.59

Related Compounds