d(-)penicillamine hydrochloride

Names

[ CAS No. ]:
2219-30-9

[ Name ]:
d(-)penicillamine hydrochloride

[Synonym ]:
Penicillamine Hydrochloride
(2S)-2-amino-3-mercapto-3-methyl-butyric acid hydrochloride
D-Penicillamin Hydrochlorid
usafa-1705
D-Penicilamine hydrochloride
(S)-2-amino-3-mercapto-3-methyl-butyric acid,hydrochloride
EINECS 218-727-9
3-mercapto-,hydrochloride,d-valin
3-mercapto-D-Valine hydrochloride
D-penicillamine hydrochloride
usafel-23
D-PENICILLAMINEHCL

Chemical & Physical Properties

[ Density]:
1.204g/cm3

[ Boiling Point ]:
251.8ºC at 760mmHg

[ Molecular Formula ]:
C5H12ClNO2S

[ Molecular Weight ]:
185.67200

[ Flash Point ]:
106.1ºC

[ Exact Mass ]:
185.02800

[ PSA ]:
102.12000

[ LogP ]:
1.60900

[ Vapour Pressure ]:
0.00631mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YV9450000
CHEMICAL NAME :
Valine, 3-mercapto-, hydrochloride, D-
CAS REGISTRY NUMBER :
2219-30-9
LAST UPDATED :
199506
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C5-H11-N-O2-S.Cl-H
MOLECULAR WEIGHT :
185.69
WISWESSER LINE NOTATION :
SHX1&1&YZVQ &GH -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
5460 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,838,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
6257 mg/kg/2Y-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960- Volume(issue)/page/year: 121,665,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4271 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 14,153,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 14,837,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 14,837,1969 *** REVIEWS *** TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 12,601,1978

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
20/21/22-40

[ Safety Phrases ]:
S22;S36

[ RTECS ]:
YV9450000

[ HS Code ]:
2930909090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%


Related Compounds