2-(2,6-Dioxopiperidin-3-yl)-5-(prop-2-yn-1-yloxy)isoindoline-1,3-dione

Names

[ Name ]:
2-(2,6-Dioxopiperidin-3-yl)-5-(prop-2-yn-1-yloxy)isoindoline-1,3-dione

[Synonym ]:
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-
2-(2,6-dioxopiperidin-3-yl)-5-(prop-2-yn-1-yloxy)isoindoline-1,3-dione

Biological Activity

[Description]:

Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon[1]

[References]

[1]. Crew, et al. Preparation of tau-protein targeting bifunctional compounds (PROTACS) as E3 ubiquitin ligase binding useful in treatment and prevention of diseases. United States, US20180125821 A1. 2018-05-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂N₂O₅

[ Molecular Weight ]:
312.28

[ Storage condition ]:
2-8°C