KRAS G12C inhibitor 17

Names

[ CAS No. ]:
2349393-04-8

[ Name ]:
KRAS G12C inhibitor 17

Biological Activity

[Description]:

KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C:5 nM (IC50)


[References]

[1]. Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H20ClF2N3O3

[ Molecular Weight ]:
471.88

Related Compounds