Carbonic anhydrase inhibitor 14

Names

[ CAS No. ]:
2410402-75-2

[ Name ]:
Carbonic anhydrase inhibitor 14

Biological Activity

[Description]:

Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with Ki values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC50 of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK2:20.3 μM (IC50)

hCA I:1203 nM (Ki)

hCA II:99.7 nM (Ki)

hCA IX:9.4 nM (Ki)

hCA XII:27.7 nM (Ki)


[References]

[1]. Said MA, et al. Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem. 2020 Mar 1;189:112019.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H17N7O2S

[ Molecular Weight ]:
395.44

Related Compounds