Keap1-Nrf2-IN-5

Names

[ CAS No. ]:
2696272-70-3

[ Name ]:
Keap1-Nrf2-IN-5

Biological Activity

[Description]:

Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 4.1 µM, Kd of 3.7 µM[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Research Areas >> Inflammation/Immunology

[Target]

IC50: 4.1 µM (Keap1-Nrf2); Kd: 3.7 µM[1]

[References]

[1]. Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₀N₄O₆S

[ Molecular Weight ]:
490.57

Related Compounds