Antimalarial agent 16

Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM)[1].

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

IC50: 2.0 nM (P. falciparum)[1]

Antimalarial agent 16 (i.p.; 40 or 200 mg/kg; once daily; 4 days) exhibits significant in vivo antimalarial effects[1]. Animal Model: Plasmodium berghei (P. berghei) ANKA infected ICR mouse[1] Dosage: 40 or 200 mg/kg Administration: Intraperitoneal injection; 40 or 200 mg/kg; once daily; 4 days Result: Inhibited malaria parasite growth effectively and retained parasitemia levels until day 8 post-infection at a dose of 40 mg/kg, attenuated parasitemia levels until day 8. Maintained survival rates until day 11 post-infection, but the rates decreased rapidly after day 11 at a dose of 40 mg/kg, observed a significant enhancement in survival a dose of 200 mg/kg.

[1]. Nobuo Cho, et al. New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety. Bioorg Med Chem. 2022 Jul 15;66:116830.