ALK5-IN-33

Names

[ CAS No. ]:
2785430-89-7

[ Name ]:
ALK5-IN-33

Biological Activity

[Description]:

ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

ALK5:≤10 nM (IC50)

ALK2


[In Vitro]

ALK-IN-33 (Compound EX-10) shows a high efficiency by inducing a full inhibition (max PIN greater than 75) of TGF-β1 mediated alpha-SMA expression, in at least two donors[1].

[In Vivo]

ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice[1]. Animal Model: Female athymic nude mice, A549 xenograft model[1] Dosage: 10, 50, 75 and 100 mg/kg Administration: Oral gavage, once Result: Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion.

[References]

[1]. Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H23N7O

[ Molecular Weight ]:
413.48

Related Compounds