1-Methylhistamine-d3 dihydrochloride

Names

[ CAS No. ]:
344299-49-6

[ Name ]:
1-Methylhistamine-d3 dihydrochloride

[Synonym ]:
Nt-Methyl-d3-histaMine 2HCl
N-Methyl-D3-histamineHCl
NT-METHYL-D3-HISTAMINE DIHYDROCHLORIDE
N'-Methyl-D3-histamine2HCl

Biological Activity

[Description]:

1-Methylhistamine-d3 (dihydrochloride) is the deuterium labeled 1-Methylhistamine (dihydrochloride)[1]. 1-Methylhistamine dihydrochloride is a histamine metabolite[2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Saito K, et al. Determination of urinary excretion of histamine and 1-methylhistamine by liquid chromatography. J Chromatogr B Biomed Appl. 1994 Apr 1;654(2):270-5.  

Chemical & Physical Properties

[ Molecular Formula ]:
C6H10Cl2D3N3

[ Molecular Weight ]:
201.11200

[ Exact Mass ]:
200.06700

[ PSA ]:
43.84000

[ LogP ]:
2.22560

Related Compounds