Glyceryl Tri(octanoate-d15)

Names

[ CAS No. ]:
352431-24-4

[ Name ]:
Glyceryl Tri(octanoate-d15)

[Synonym ]:
Glyceryl Tri(octanoate-d15)
Propane-1,2,3-triyl tri(H)octanoate
1,2,3-Propanetriyl tri(H)octanoate
Octanoic-d acid, 1,2,3-propanetriyl ester

Biological Activity

[Description]:

Tricaprilin-d15 is the deuterium labeled Tricaprilin. Tricaprilin (Trioctanoin) is used in study for patients with mild to moderate Alzheimer's disease and has a role as an anticonvulsant and a plant metabolite[1][2].

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Tricaprylin

[3]. Kwok MK, et al. Re-thinking Alzheimer's disease therapeutic targets using gene-based tests. EBioMedicine. 2018 Nov;37:461-470.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
508.0±17.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H5D45O6

[ Molecular Weight ]:
515.96

[ Flash Point ]:
209.3±21.0 °C

[ Exact Mass ]:
515.643188

[ PSA ]:
78.90000

[ LogP ]:
9.33

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.458

Related Compounds