(2S)-2-Amino(3,3-2H2)butanoic acid

Names

[ CAS No. ]:
352431-37-9

[ Name ]:
(2S)-2-Amino(3,3-2H2)butanoic acid

[Synonym ]:
(2S)-2-Amino(3,3-H)butanoic acid
Butanoic-3,3-d acid, 2-amino-, (2S)-

Biological Activity

[Description]:

H-Abu-OH-d2 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Yudkoff M, et al. On the clinical significance of the plasma alpha-amino-n-butyric acid:leucine ratio. Am J Clin Nutr. 1979 Feb;32(2):282-5.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
215.2±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C4H7D2NO2

[ Molecular Weight ]:
105.13

[ Flash Point ]:
83.9±22.6 °C

[ Exact Mass ]:
105.075882

[ PSA ]:
63.32000

[ LogP ]:
-0.15

[ Vapour Pressure ]:
0.1±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.462

Related Compounds