8-Hydroxy-2'-deoxyguanosine-15N5

Names

[ CAS No. ]:
569649-11-2

[ Name ]:
8-Hydroxy-2'-deoxyguanosine-15N5

Biological Activity

[Description]:

8-Hydroxy-2'-deoxyguanosine-15N5 is the 15N labeled 8-Hydroxy-2'-deoxyguanosine[1]. 8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis[2].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Valavanidis A, et al. 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H1315N5O5

[ Molecular Weight ]:
288.21

Related Compounds