(+)-B-HYDRASTINE HCL

Names

[ Name ]:
(+)-B-HYDRASTINE HCL

[Synonym ]:
ISOCORYNE HYDROCHLORIDE
(1R,9S)-B-hydrastine hydrochloride
HydrastineHCl
HYDRASTINE HCL,(+)-B
HYDRASTINE HCl,(+)-B-(P)
(S)-6,7-dimethoxy-3-((R)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one,hydrochloride
HYDRASTINE HYDROCHLORIDE

Chemical & Physical Properties

[ Boiling Point ]:
548.8ºC at 760 mmHg

[ Melting Point ]:
115ºC

[ Molecular Formula ]:
C₂₁H₂₂ClNO₆

[ Molecular Weight ]:
419.85500

[ Flash Point ]:
285.7ºC

[ Exact Mass ]:
419.11400

[ PSA ]:
66.46000

[ LogP ]:
3.61310

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MU6125000

CHEMICAL NAME :: Hydrastine hydrochloride

CAS REGISTRY NUMBER :: 5936-28-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H21-N-O6.Cl-H

MOLECULAR WEIGHT :: 419.89

WISWESSER LINE NOTATION :: T C566 DO FO KN EH&&TJ K1 J- DT56 BVO DHJ HO1 IO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,57,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,57,1969

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ Safety Phrases ]:
36

[ RIDADR ]:
UN 1544

[ RTECS ]:
MU6125000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Expanding the repertoire of small molecule transcriptional activation domains.

Bioorg. Med. Chem. 17 , 1034-43, (2009)

Molecules that can reconstitute the function of transcriptional activators hold enormous potential as therapeutic agents and as mechanistic probes. Previously we described an isoxazolidine bearing fun...

Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism.

J. Neurophysiol. 86(5) , 2363-73, (2001)

The discharge patterns of respiratory neurons of the caudal ventral respiratory group (cVRG) appear to be subject to potent GABAergic gain modulation. Local application of the GABA(A) receptor antagon...

Effects of (1R,9S)-beta-hydrastine on l-DOPA-induced cytotoxicity in PC12 cells.

Eur. J. Pharmacol. 488(1-3) , 71-7, (2004)

(1R,9S)-beta-Hydrastine in lower concentrations of 10-50 microM inhibits dopamine biosynthesis in PC12 cells. In this study, the effects of (1R,9S)-beta-hydrastine on L-DOPA (L-3,4-dihydroxyphenylalan...