Anticonvulsant agent 2

Names

[ CAS No. ]:
75220-84-7

[ Name ]:
Anticonvulsant agent 2

Biological Activity

[Description]:

Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent. Anticonvulsant agent 2 shows antiepileptic activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vivo]

Anticonvulsant agent 2 (compound10 a; 50 mg/kg, p.o.) 降低大鼠运动活性，抑制率为 21.01%[1]。 Anticonvulsant agent 2 (50 mg/kg; p.o.) 显示出抗癫痫活性，对大鼠的抑制率为24.45%[1]。 Animal Model: 180-250g, male Wistar rats[1] Dosage: 50 mg/kg Administration: P.o. Result: Showed antiepileptic activity with the inhibition rate of 24.45%.

[References]

[1]. Verma R, et al. Design, synthesis and neuropharmacological evaluation of new 2,4-disubstituted-1,5-benzodiazepines as CNS active agents. Bioorg Chem. 2020 Aug;101:104010.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H17ClN2

[ Molecular Weight ]:
332.83

[ Exact Mass ]:
332.10800

[ PSA ]:
24.39000

[ LogP ]:
5.59130

Synthetic Route

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Precursor & DownStream

Precursor

DownStream