UCK2 Inhibitor-2

Names

[ CAS No. ]:
866842-71-9

[ Name ]:
UCK2 Inhibitor-2

Biological Activity

[Description]:

UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

IC50: 3.8 µM (UCK2)[1]


[In Vitro]

UCK2 Inhibitor-2 (compound 20874830) 在浓度为 50 µM 时对 K562 细胞中的尿苷补救有 52% 的抑制作用。DHODH 的抑制增加了尿苷的回收，而 UCK2 抑制剂 UCK2 Inhibitor-2 (compound 20874830) 可以抑制这种增加[1]。

[References]

[1]. Ayse Okesli-Armlovich, et al. Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2559-2564.  

Chemical & Physical Properties

[ Molecular Formula ]:
C28H23N3O4S

[ Molecular Weight ]:
497.56

Related Compounds