Combretastatin A4 disodium phosphate (CA4P) Price from Supplier Brand Chemleader Biomedical Co., Ltd. on Chemsrc.com

Published date: 2024-01-10 15:03:19

CAS number: 168555-66-6

Name: Combretastatin A4 disodium phosphate

Price:
￥Inquiry/1g ￥Inquiry/5g ￥Inquiry/10g ￥Inquiry/50g

Purity: 99.0%

Stocking period: Inquiry

Stock: In Stock

Detail Product Information:
Product Name: Combretastatin A4 disodium phosphate(CA4P); Fosbretabulin disodium; Combretastatin A-4 phosphate, disodium salt
CAS No.: 168555-66-6
Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol dihydrogen phosphate disodium salt
Molecular Formula:C18H19Na2O8P
Molecular Weight: 440.30
Appearance:White or off-white solid
Purity(HPLC):>99%
Biological Activity:

Combretastatin A4 Phosphate Disodium Salt is the salt form of Combretastatin A4, a phosphorylated microtubule depolymerizing molecule which induces tumor necrosis by regression of unstable nascent tumor neo-vessels. Studies suggest that Combretastatin A4 Phosphate Disodium Salt selectively inhibits endothelial tumor cells via disrupting VE-cadherin (vascular endothelial-cadherin). In addition, Combretastatin A4 Phosphate Disodium Salt can increase the permeability of endothelial cells while inhibiting their migration and suppress capillary tube formation via disruption of VE-cadherin. Furthermore, Combretastatin A4 Phosphate Disodium Salt can change the morphology of endothelial cells by altering their tubulin cytoskeleton. Combretastatin A-4 phosphate (fosbretabulin) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.

Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell–specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue.

Name: Chemleader Biomedical Co., Ltd.

Chemsrc Level: Unverified

Product #: 40

Tel: +8621-58180488

Address: 5/F,Building 25,No.3399 Kangxin Highway,Shanghai International Medical Zone(SIMZ),Pudong New District,Shanghai 201318, P.R. China

Area: China(Mainland)

Contact: Chemleader

Contact Phone #: +8621-58180488

Email: sales@chemleader.cn

Website: http://www.chemleader.com.cn

Detail introduction:
Chemleader Biomedical Co., Ltd. was founded in 2010, is a professional research chemical supplier specializing in R&D, manufacturing and sales. The headquarters is located in Shanghai International Medical Zone(SIMZ), Pudong New District, Shanghai, China, with over 30000 square feet sales office/ research laboratory and 20000 square feet pilot plant. Our branches in Jiangsu, Shandong, and Hong Kong.
We are committed to provide the highest quality products and the best service to pharmaceutical company and scientific research institutions in China and international markets. Our team has had extensive expertise and an excellent background in synthetic chemistry, project management, CRO, QC/QA, pilot plant etc.
As an innovation-driven and customer-focused company, we also specialize in custom synthesis of organic compounds, various drug intermediates as well as a variety of specialty and fine chemicals ranging from milligram to tons scale.

With our whole Professional team's efforts for many years we gain the admiration and trust from the domestic and overseas clients, and favorable position and Reputation in China Pharmaceutical and Fine Chemicals field. We are devoted to decreasing the production cost, optimizing the artwork, creating and keeping the accomplishment of best environmental, health, and safety performance in the industry.

Core Values:
"Customer First" "People-Oriented" "Sustainable Innovation" "Teamwork"

Mission:
To be a leader in the global pharmaceutical and chemical research and development field by providing our clients with top quality products and service.

Vision:
To be recognized by its clients as the best pharmaceutical partner for its superior quality, efficient and cost-effective services;
To be recognized by its competitors as a responsible and competitive team for its spirits of innovation, matter-of-fact attitude, high efficiency of operations and the strategy of sustainable growth .
To be recognized by its employees as a respectable employer for offering professional training, and career opportunities.