Published date: 2024-07-17 15:06:30
CAS number: 39674-97-0
Name: BVT 948
Price:
$800.0/100mg
$1300.0/250mg
$2700.0/1g
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
Product Webpage: https://www.dcchemicals.com/product_show-DC21685.html
Detail Product Information:
BVT-948 (SPS8I-3) is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) with IC50 of 0.09-1.7 uM. Results show that the effect of BVT948 (BVT.948) is to strengthen the insulin signal and has no effects on the duration of the signal. BVT948 appears to be an effective inhibitor of both protein tyrosine phosphatases (PTP activity and P450 activity)[1]. BVT948 efficiently and selectively suppresses cellular H4 lysine 20 (H4K20me1) at doses lower than 5 μM within 24 h. The cells treated with BVT948 recapitulate cell-cycle-arrest phenotypes similar to what are reported for knocking down SETD8 by RNAi[2]. Treatment of MCF-7 cells with 0.5, 1 or 5 μM of BVT948 for 24 h does not cause any significant changes in cell viability. BVT948 inhibits TPA-induced MMP-9 up-regulation in a dose-dependent manner. Treatment with BVT948 inhibits TPA-stimulated NF-κB binding activity, but not AP-1 binding activity. BVT948 does not affect the MAPK phosphorylation by TPA. Treatment with BVT948 diminishes the TPA-induced cell invasion by 50%[3].Results show that 3 μmol/kg BVT948 (BVT.948) significantly enhances glucose clearance from the blood stream in response to insulin compare with vehicle-treated controls[1].
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 34949
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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introduction:
D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.
D&C Chem has established a global network of thousands of customers from many research centers and Reagent companies in the USA, Europe and Japan.
We are the the official vendor of more than 500 universities and institutes including: Harvard University,Yale University,NIH/NCI, City of Hope ORG, PARTNERS ORG,John Hopkins University,Universit tsklinikum,Oxford University,Newcastle University,UNC,UCSF and many other universities and institutes. Our bioactive compounds received good feedback from our customers.
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Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$800.0/100mg
$1300.0/250mg
$2700.0/1g
Contact: Huang
Product Detail: 4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE
Name: DC Chemicals Limited
Area: China
Price:
$800.0/100mg
$1300.0/250mg
$2700.0/1g
Contact: Tony Cao
Product Detail: BVT-948
Name: ShangHai DC Chemicals Co.,Ltd
Area: China
Price:
$800.0/100mg
$1300.0/250mg
$2700.0/1g
Contact: Tony Lai
Product Detail: BVT-948
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