Published date: 2024-07-17 15:06:34
CAS number: 2138861-99-9
Name: ABBV-744
Price:
$600.0/100mg
$980.0/250mg
$1900.0/1g
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
Product Webpage: https://www.dcchemicals.com/product_show-ABBV-744.html
Detail Product Information:
ABBV-744 is a BDII-selective BET bromodomain inhibitor that is being investigated to treat AML and metastic castration-resistant prostate cancer.BBV-744, a highly potent and selective inhibitor of the BD2 domain of BET family proteins with drug-like properties. In contrast to the broad range of cell growth inhibition induced by DbBi, the antiproliferative activity of ABBV-744 was largely, but not exclusively, restricted to cell lines of acute myeloid leukaemia and prostate cancer that expressed the full-length androgen receptor (AR). ABBV-744 retained robust activity in prostate cancer xenografts, and showed fewer platelet and gastrointestinal toxicities than the DbBi ABBV-07514.Analyses of RNA expression and chromatin immunoprecipitation followed by sequencing revealed that ABBV-744 displaced BRD4 from AR-containing super-enhancers and inhibited AR-dependent transcription, with less impact on global transcription compared with ABBV-075. These results underscore the potential value of selectively targeting the BD2 domain of BET family proteins for cancer therapy.
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 34949
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$600.0/100mg
$980.0/250mg
$1900.0/1g
Contact: Huang
Product Detail: ABBV-744
Name: DC Chemicals Limited
Area: China
Price:
$600.0/100mg
$980.0/250mg
$1900.0/1g
Contact: Tony Cao
Product Detail: ABBV-744
Name: ShangHai DC Chemicals Co.,Ltd
Area: China
Price:
$600.0/100mg
$980.0/250mg
$1900.0/1g
Contact: Tony Lai
Product Detail: ABBV-744
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