Published date: 2024-07-17 15:06:25
CAS number: 849214-04-6
Name: cGAMP
Price:
$350.0/5mg
$990.0/25mg
$550.0/10mg
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
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3’3’-cGAMP Fluorinated (c-[2'FdGMP]-[2'FdAMP]) is a synthetic analog of cyclic guanosine monophosphate- adenosine monophosphate (cyclic GMP-AMP, cGAMP) with a fluorine atom at 2’ position of the nucleosides. 3’3’-cGAMP is a cyclic di-nucleotide produced by bacteria. It is also referred to as "canonical" cGAMP due the presence of the classical 3’-5’ phosphodiester linkages between the guanosine and the adenosine. It has been reported that cGAMP binds STING (stimulator of IFN genes) and subsequently induces TBK1-IRF3-dependent production of IFN-β [1].
The incorporation of fluorine into biologically active molecules is commonly used in medicinal chemistry to improve their metabolic stability or to modulate physicochemical properties such as lipophilicity [2, 3]. Moreover, the introduction of a fluorine atom can change the biological activities of a molecule. Interestingly, when used at low concentrations in various cellular assays, 3’3’-cGAMP Fluorinated induces higher levels of type I IFNs than does cGAMP.
STING ligands such as cGAMP induce type I IFNs and activate interferon stimulated genes (ISG) through IRFs. To facilitate their study, InvivoGen has developed stable reporter cells in two well established immune cell models: THP-1 human monocytes and RAW 264.7 murine macrophages. These cells express a reporter gene (SEAP or Lucia luciferase), under control of an IRF-inducible promoter.
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Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$350.0/5mg
$990.0/25mg
$550.0/10mg
Contact: Huang
Product Detail: cGAMP
Name: DC Chemicals Limited
Area: China
Price:
$350.0/5mg
$990.0/25mg
$550.0/10mg
Contact: Tony Cao
Product Detail: 3'3'-cGAMP (sodium salt)
Name: ShangHai DC Chemicals Co.,Ltd
Area: China
Price:
$350.0/5mg
$990.0/25mg
$550.0/10mg
Contact: Tony Lai
Product Detail: 3'3'-cGAMP (sodium salt)
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