Published date: 2024-07-17 15:06:30
CAS number: 850173-95-4
Name: ADL5859 HCl
Price:
$450.0/100mg
$900.0/250mg
$1800.0/1g
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
Product Webpage: https://www.dcchemicals.com/product_show-ADL5859_HCl.html
Detail Product Information:
ADL5859 agonizes δ-opioid receptor with a 1000-fold selectivity than µ- or κ-opioid receptor with Ki of 32 nM and 37 nM, respectively.ADL5859 displays weak inhibitory activity at the hERG channel with an IC50 of 78 μM. The EC50 of ADL5859 against δ opioid receptor is 20 nM. At the screening dose of 3 mg/kg p.o., ADL5859 produces 100% reversal of hyperalgesia in the inflamed paw. The oral ED50 of ADL5859 in the FCA mechanical hyperalgesia assay is 1.4 mg/kg. The antihyperalgesia produced by ADL5859 (3 mg/kg, p.o.) is reversed by pretreatment with the δ opioid antagonist naltrindole (0.3 mg/kg s.c.), thus demonstrating a δ receptor mediated effect.In the rat Forced swim assay, ADL5859 (3 mg/kg p.o.) produces robust antidepressant-like activity, as evidenced by a significant decrease in the time spent immobile and a significant increase in the time spent swimming. The bioavailability of ADL5859 (3 mg/kg p.o.) in rats and dogs is 33% and 66%, respectively.ADL5859 efficiently reduces inflammatory and neuropathic pain mainly by recruiting δ-opioid receptors expressed by peripheral Nav1.8-expressing neurons.For the detailed information of ADL5859 HCl, the solubility of ADL5859 HCl in water, the solubility of ADL5859 HCl in DMSO, the solubility of ADL5859 HCl in PBS buffer, the animal experiment (test) of ADL5859 HCl, the cell expriment (test) of ADL5859 HCl, the in vivo, in vitro and clinical trial test of ADL5859 HCl, the EC50, IC50,and Affinity of ADL5859 HCl, Please contact DC Chemicals..
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 34952
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$450.0/100mg
$900.0/250mg
$1800.0/1g
Contact: Yang
Product Detail: ADL5859HCl
Name: ShangHai DC Chemicals Co.,Ltd
Area: China
Price:
$450.0/100mg
$900.0/250mg
$1800.0/1g
Contact: Tony Lai
Product Detail: ADL5859 HCl
Name: DC Chemicals Limited
Area: China
Price:
$450.0/100mg
$900.0/250mg
$1800.0/1g
Contact: Tony Cao
Product Detail: ADL5859 HCl
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