Published date: 2024-07-17 15:06:36
CAS number: 2138300-40-8
Name: STING agonist diABZI compound 2
Price:
$1600.0/50mg
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
Product Webpage: https://www.dcchemicals.com/product_show-STING_agonist_diABZI_compound_2.html
Detail Product Information:
STING agonist 4 is an amidobenzimidazole (ABZI)-based compound that functions as a STING agonist with Kd of 1.6 nM (binding of endogenous full-length STING, THP-1 cell lysates); caused dose-dependent phosphorylation of IRF3 and STING that was inhibited by the TBK1 inhibitor BX795, induced dose-dependent secretion of IFN-β with EC50 of 3.1 uM in PBMCs (18-fold more potent than cGAMP); promotes production of IFN-γ-induced protein 10 (IP-10), IL-6 and TNFα by a mechanism that is dependent on STING-mediated activation of TBK1; unlike cGAMP and DMXAA, compound 2 efficiently activates STING function while maintaining an open STING confirmation.
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Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$1600.0/50mg
Contact: Huang
Product Detail: STING agonist-4
Name: ShangHai DC Chemicals Co.,Ltd
Area: China
Price:
$1600.0/50mg
Contact: Tony Lai
Product Detail: STING agonist-4
Name: DC Chemicals Limited
Area: China
Price:
$1600.0/50mg
Contact: Tony Cao
Product Detail: STING agonist-4
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