PAP-1 Price from Supplier Brand DC Chemicals Limited on Chemsrc.com

Published date: 2024-07-17 15:06:38

CAS number: 870653-45-5

Name: PAP-1

Price:
$320.0/50mg $500.0/100mg $900.0/250mg

Purity: 98.0%

Stocking period: 3 Day

Stock: 3

Product Webpage: https://www.dcchemicals.com/product_show-DC23946.html

Detail Product Information:
PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. IC50 value: 2 nM (EC50) [1]in vitro: blocks Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and an EC50 of 2 nM, by preferentially binding to the C-type inactivated state of the channel. PAP-1 is 23-fold selective over Kv1.5, 33- to 125-fold selective over other Kv1-family channels, and 500- to 7500-fold selective over Kv2.1, Kv3.1, Kv3.2, Kv4.2, HERG, calcium-activated K+ channels, Na+,Ca2+, and Cl- channels [1]. The blockade of Kv1.3 results in membrane depolarization and inhibition of TEM proliferation and function. In this study, the in vitro effects of PAP-1 on T cells and the in vivo toxicity and pharmacokinetics (PK) were examined in rhesus macaques (RM) with the ultimate aim of utilizing PAP-1 to define the role of TEMs in RM infected with simian immunodeficiency virus (SIV). Electrophysiologic studies on T cells in RM revealed a Kv1.3 expression pattern similar to that in human T cells. Thus, PAP-1 effectively suppressed TEM proliferation in RM [2].in vivo: PAP-1 does not exhibit cytotoxic or phototoxic effects, is negative in the Ames test, and affects cytochrome P450-dependent enzymes only at micromolar concentrations. PAP-1 potently inhibits the proliferation of human TEM cells and suppresses delayed type hypersensitivity, a TEM cell-mediated reaction, in rats [1]. When administered intravenously, PAP-1 showed a half-life of 6.4 hrs; the volume of distribution suggested extensive distribution into extravascular compartments. When orally administered, PAP-1 was efficiently absorbed. Plasma concentrations in RM undergoing a 30-day, chronic dosing study indicated that PAP-1 levels suppressive to TEMs in vitro can be achieved and maintained in vivo at a non-toxic dose [2].

Name: DC Chemicals Limited Recommended

Chemsrc Level: Verified

Product #: 34952

Tel: 58447131

Address: Jinyu Rd100, pudong

Area: China(Mainland)

Contact: Tony Cao

Contact Phone #: 13564518121

Email: sales@dcchemicals.com

Website: http://www.dcchemicals.com

Detail introduction:
D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.

D&C Chem has established a global network of thousands of customers from many research centers and Reagent companies in the USA, Europe and Japan.

We are the the official vendor of more than 500 universities and institutes including: Harvard University,Yale University,NIH/NCI, City of Hope ORG, PARTNERS ORG,John Hopkins University,Universit tsklinikum,Oxford University,Newcastle University,UNC,UCSF and many other universities and institutes. Our bioactive compounds received good feedback from our customers.

Our credo is committed to the adoption of different products, reliable quality, competitive prices and quality service to create value for customers.

Name: Shanghai Nianxing Industrial Co., Ltd

Area: China

Price:
$320.0/50mg $500.0/100mg $900.0/250mg

Contact: Yang

Product Detail: PAP-1

Name: Shanghai Jizhi Biochemical Technology Co., Ltd

Area: China

Price:
$320.0/50mg $500.0/100mg $900.0/250mg

Contact: Liu jia

Product Detail: PAP-1

Name: DC Chemicals Limited

Area: China