Cinnamaldehyde
Names
[ CAS No. ]:
104-55-2
[ Name ]:
Cinnamaldehyde
[Synonym ]:
(E)-3-phenylprop-2-enal
trans-Cinnamic Aldehyde
(2E)-3-Phenyl-2-propenal
Cinnamaldehyde, (E)-
trans-Cinnamylaldehyde
2-Propenal, 3-phenyl-, (2E)-
β-phenylacrolein
Cinnamic aldehyde
(2E)-3-phenylprop-2-enal
(E)-3-phenylpropenal
cinnamic aldehyde, (E)-isomer
Cinnamyl aldehyde
(E)-3-Phenyl-propenal
2-Propenal, 3-phenyl-, (E)- (9CI)
trans-3-Phenylacrolein
3-Phenylacrolein
trans-Phenylacrolein
Acrolein, 3-phenyl-
(2E)-3-Phenylacrylaldehyde
MFCD00007000
4-07-00-00984 (Beilstein Handbook Reference)
trans-Cinnamaldehyde
(E)-cinnamaldehyde
EINECS 203-213-9
Cinnamaldehyde, trans-
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
246.8±9.0 °C at 760 mmHg
[ Melting Point ]:
-7.5ºC
[ Molecular Formula ]:
C9H8O
[ Molecular Weight ]:
132.159
[ Flash Point ]:
71.1±0.0 °C
[ Exact Mass ]:
132.057510
[ PSA ]:
17.07000
[ LogP ]:
2.12
[ Vapour density ]:
4.6 (vs air)
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.577
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
[ Water Solubility ]:
Slightly soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GD6475000
- CHEMICAL NAME :
- Cinnamaldehyde
- CAS REGISTRY NUMBER :
- 104-55-2
- BEILSTEIN REFERENCE NO. :
- 0605737
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 25
- MOLECULAR FORMULA :
- C9-H8-O
- MOLECULAR WEIGHT :
- 132.17
- WISWESSER LINE NOTATION :
- VH1U1R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Human
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2220 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2225 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1160 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 35 mg/kg/24W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8092 mg/kg/17W-I
- TOXIC EFFECTS :
- Liver - liver function tests impaired
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 55 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 275 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Fibroblast
- DOSE/DURATION :
- 15 mg/L
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** REVIEWS *** TOXICOLOGY REVIEW DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 1(5),5,1981 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83182 No. of Facilities: 372 (estimated) No. of Industries: 14 No. of Occupations: 38 No. of Employees: 13984 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83182 No. of Facilities: 6159 (estimated) No. of Industries: 58 No. of Occupations: 76 No. of Employees: 111108 (estimated) No. of Female Employees: 43381 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H317-H319-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
26-36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
GD6476000
[ Packaging Group ]:
I; II; III
[ Hazard Class ]:
6.1
[ HS Code ]:
2912299000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2912190090
[ Summary ]:
2912190090 acyclic aldehydes without other oxygen function。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
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