Br-C3-methyl ester

Names

[ Name ]:
Br-C3-methyl ester

[Synonym ]:
Butanoic acid, 4-bromo-, methyl ester
MFCD00041482
Butyric acid, 4-bromo-, methyl ester
EINECS 225-523-3
4-Bromobutyric Acid Methyl Ester
Methyl 4-bromobutanoate
Methyl 4-bromobutyrate

Biological Activity

[Description]:

Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Binbin Cheng, et al. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
186.5±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₉BrO₂

[ Molecular Weight ]:
181.028

[ Flash Point ]:
87.0±13.0 °C

[ Exact Mass ]:
179.978592

[ PSA ]:
26.30000

[ LogP ]:
1.47

[ Vapour Pressure ]:
0.7±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.456

[ Storage condition ]:
Room temperature.

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ HS Code ]:
2915900090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Related Compounds

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