Glycoursodeoxycholic acid

Names

[ Name ]:
Glycoursodeoxycholic acid

[Synonym ]:
Glycoursodeoxycholic Acid

Biological Activity

[Description]:

Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.In Vitro: The antioxidant compound glycoursodeoxycholic acid (GUDCA) fully abrogates UCB-induced cytochrome c oxidase inhibition and significantly prevents oxidative stress, metabolic alterations, and cell demise[1].GUDCA has shown therapeutic efficacy in neurodegenerative models and diseases. Increased cytosolic SOD1 inclusions were observed in 4 DIV NSC-34/hSOD1(G93A) cells together with decreased mitochondria viability, caspase-9 activation, and apoptosis[2]. Glycoursodeoxycholic acid shows preventive and restorative effects against unconjugated bilirubin -induced blood-brain barrier disruption and damage to human brain microvascular endothelial cells[3].

[Related Catalog]:

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
232-235ºC

[ Molecular Formula ]:
C₂₆H₄₃NO₅

[ Molecular Weight ]:
449.62300

[ Exact Mass ]:
449.31400

[ PSA ]:
106.86000

[ LogP ]:
3.98500

[ Storage condition ]:
-20°C Freezer

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Ultra high resolution SFC-MS as a high throughput platform for metabolic phenotyping: application to metabolic profiling of rat and dog bile.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 966 , 200-7, (2014)

Ultra high resolution SFC-MS (on sub-2μm particles) coupled to mass spectrometry has been evaluated for the metabolic profiling of rat and dog bile. The selectivity of the SFC separation differed from...

A possible role of chenodeoxycholic acid and glycine-conjugated bile acids in fibrotic steatohepatitis in a dietary rat model.

Dig. Dis. Sci. 59(7) , 1490-501, (2014)

Our previous study indicated that hepatic bile acids (BAs) may have deposited and stimulated the pathogenesis of a high fat-cholesterol (HFC) diet-induced fibrotic steatohepatitis in stroke-prone spon...

A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids.

J. Chromatogr. A. 1371 , 184-95, (2014)

Recently, hydroxy sterols and bile acids have gained growing interest as they are important regulators of energy homoeostasis and inflammation. The high number of different hydroxy sterols and bile ac...