Published date: 2024-07-17 15:06:31
CAS number: 2765218-56-0
Name: 3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]-
Price:
￥350.0/10mg
￥800.0/100mg
￥1350.0/250mg
Purity: 98.0%
Stocking period: 1 Day
Stock: 3
Product Webpage: http://www.dcchemicals.com
Detail Product Information:
YAP activator PY-60 (PY-60) is a novel small molecule activator of YAP tranional activity (EC50=1.5 uM) via targeting annexin A2 (ANXA2).
PY-60 dose-dependently induced luciferase activity in 293A-TEAD-LUC cells, robustly activateed YAP tranional activity in vitro.
PY-60 treatment robustly increased the levels of YAP-controlled trans (ANRKD1, CYR61 and CTGF) in 293A cells and other human cell lines (MCF10A, HEK293T, H69 and HaCaT), but did not augment the levels of YAP itself (YAP1).
PY-60 promotes YAP-dependent expansion of epidermal keratinocytes in mouse following topical drug administration. Annexin A2 (ANXA2) is a protein that directly associates with YAP at the cell membrane in response to increased cell density.
PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and tranionally active form of YAP.
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 34949
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
Detail
introduction:
D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.
D&C Chem has established a global network of thousands of customers from many research centers and Reagent companies in the USA, Europe and Japan.
We are the the official vendor of more than 500 universities and institutes including: Harvard University,Yale University,NIH/NCI, City of Hope ORG, PARTNERS ORG,John Hopkins University,Universit tsklinikum,Oxford University,Newcastle University,UNC,UCSF and many other universities and institutes. Our bioactive compounds received good feedback from our customers.
Our credo is committed to the adoption of different products, reliable quality, competitive prices and quality service to create value for customers.
Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
￥350.0/10mg
￥800.0/100mg
￥1350.0/250mg
Contact: Huang
Product Detail: PY-60
Name: ShangHai DC Chemicals Co.,Ltd
Area: China
Price:
￥350.0/10mg
￥800.0/100mg
￥1350.0/250mg
Contact: Tony Lai
Product Detail: PY-60
Name: DC Chemicals Limited
Area: China
Price:
￥350.0/10mg
￥800.0/100mg
￥1350.0/250mg
Contact: Tony Cao
Product Detail: PY-60
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2024-07-15 PY-60
2022-11-29 PY-60
2024-04-03 3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]-
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