Published date: 2024-07-17 15:06:33
CAS number: 255383-10-9
Name: AMD3451
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/1g
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
Product Webpage: https://www.dcchemicals.com/product_show-amd3451.html
Detail Product Information:
AMD3451 is a specific, dual CXCR5/CXCR4 antagonist with antiviral activity against a wide variety of HIV-1 and HIV-2 (IC50=1.2 to 26.5 uM) in vitro.AMD3451 has antiviral activity against a wide variety of R5, R5/X4, and X4 strains if HIV-1 and HIV-2 in various T-cell lines, CCR5- or CXCR4-transfected cells, PBMCs, and monocytes/macrophages.AMD3451 inhibited R5, R5/X4, and X4 HIV-1 primary clinical isolates in PBMCs (IC50, 1.8 to 7.3 uM), AMD3451 blocks R5 and X4 HIV-1 infection at the virus entry stage.AMD3451 dose-dependently inhibited the intracellular Ca2+ signaling induced by the CXCR4 ligand CXCL12 in T-lymphocytic cells and in CXCR4-transfected cells, as well as the Ca2+ flux induced by the CCR5 ligands CCL5, CCL3, and CCL4 in CCR5-transfected cells.AMD3451 did not interfere with chemokine-induced Ca2+ signaling through CCR1, CCR2, CCR3, CCR4, CCR6, CCR9, or CXCR3 and did not induce intracellular Ca2+ signaling by itself at 400 uM.AMD3451 inhibited CXCL12- and CCL3L1-induced endocytosis in CXCR4- and CCR5-transfected cells.AMD3451 does not inhibit the binding of CXCR4- or CCR5-specific MAbs.
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 34949
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.
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Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/1g
Contact: Huang
Product Detail: AMD3451
Name: DC Chemicals Limited
Area: China
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/1g
Contact: Tony Cao
Product Detail: AMD3451
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