Published date: 2024-07-17 15:06:33
CAS number: 2245020-50-0
Name: AB-506
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/1g
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
Product Webpage: https://www.dcchemicals.com/product_show-ab-506.html
Detail Product Information:
AB-506 is a small-molecule inhibitor targeting HBV core protein, inhibits viral replication in vitro (IC50=77 nM).AB-506 binds to HBV core protein, accelerates capsid assembly and inhibits HBV pgRNA encapsidation.AB-506 blocks cccDNA establishment in HBV-infected HepG2-hNTCP-C4 cells and primary human hepatocytes, leading to inhibition of viral RNA, HBsAg, and HBeAg production (EC50=0.64-1.52 uM).AB-506 demonstrated activity across HBV genotypes A-H and maintains antiviral activity against nucleostide analog-resistant variants in vitro.AB-506 showed an 8 to 20-fold increase in EC50 values against L30F, L37Q, and I105T substitutions.AB-506 exhibits good oral bioavailability, systemic exposure, and higher liver to plasma ratios in rodents.
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 34952
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.
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Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/1g
Contact: Yang
Product Detail: AB-506
Name: DC Chemicals Limited
Area: China
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/1g
Contact: Tony Cao
Product Detail: AB-506
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