Published date: 2022-06-22 21:57:40
CAS number: 2401867-58-9
Name: JBJ-08-178-01
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/1g
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
Product Webpage: https://www.dcchemicals.com/product_show-jbj-08-178-01.html
Detail Product Information:
JBJ-08-178-01 is a potent, selective and covalent HER2 inhibitor with IC50 of 2.21 nM and 7.04 nM for HER2 WT and EGFR WT, targets multiple HER2 activating mutations, including exon 20 insertions as well as amplification (IC50 values<50 nM).JBJ-08-178-01 maintained potency against non-insertion mutations, including S310F, L755S, V777L, V842I, and exon 19 indel (755_757LREdelinsRP) of HER2.JBJ-08-178-01 exhibited a much greater degree of HER2-selectivity in Ba/F3 cell lines than in biochemical assays, owing to weak growth inhibition against Ba/F3 cells with WT EGFR (IC50=368 nM).JBJ-08-178-01 showed strong antitumoral activity in HER2- mutant or amplified cancers in vitro and in vivo.Treatment with JBJ-08-178-01 also led to a reduction in total HER2 by promoting proteasomal degradation of the receptor.JBJ-08-178-01 is a selective, dual-action inhibitor and destabilizer of HER2 with potential efficacy and tolerance against NSCLC harboring HER2 genetic alterations or amplification.
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 34949
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
Detail introduction:
D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.
D&C Chem has established a global network of thousands of customers from many research centers and Reagent companies in the USA, Europe and Japan.
We are the the official vendor of more than 500 universities and institutes including: Harvard University,Yale University,NIH/NCI, City of Hope ORG, PARTNERS ORG,John Hopkins University,Universit tsklinikum,Oxford University,Newcastle University,UNC,UCSF and many other universities and institutes. Our bioactive compounds received good feedback from our customers.
Our credo is committed to the adoption of different products, reliable quality, competitive prices and quality service to create value for customers.
Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/1g
Contact: Huang
Product Detail: JBJ-08-178-01
Name: DC Chemicals Limited
Area: China
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/1g
Contact: Tony Cao
Product Detail: JBJ-08-178-01
Get all suppliers by the below link: