Published date: 2024-07-17 15:06:26
CAS number: 2225938-86-1
Name: MS177
Price:
$650.0/5mg
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
Product Webpage: https://www.dcchemicals.com/product_show-ms177.html
Detail Product Information:
MS177 (MS-177) is a potent and selective EZH2 degarder (PROTAC) based on EZH2 inhibitor C24 with CRBN ligand pomalidomide with DC50 of 0.2 uM in EOL-1 cells.MS177 effectively degraded cellular EZH2-PRC2, suppressed global H3K27me3 in leukaemia cells.MS177 exhibited half-maximal degradation concentration (DC50) values of 0.2 ± 0.1 μM and 1.5 ± 0.2 μM, and maximum degradation (Dmax) values of 82% and 68%, respectively, in EOL-1 and MV4;11 cells.MS177 efficiently suppresses EZH2-PRC2 functions, also efficiently induces Myc degradation in cancer cells, suppresses EZH2-PRC2 functions.MS177 efficiently induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest, which is more effective than EZH2 inhibitors. MS177 (i.p. injection, 50-1 g/kg) represses AML growth without apparent toxicity in PDX models.
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 34952
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$650.0/5mg
Contact: Yang
Product Detail: MS177
Name: ShangHai DC Chemicals Co.,Ltd
Area: China
Price:
$650.0/5mg
Contact: Tony Lai
Product Detail: MS177
Name: DC Chemicals Limited
Area: China
Price:
$650.0/5mg
Contact: Tony Cao
Product Detail: MS177
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