BVT-948 Price from Supplier Brand ShangHai DC Chemicals Co.,Ltd on Chemsrc.com

Published date: 2024-01-23 10:46:16

CAS number: 39674-97-0

Price:
￥Inquiry/1g

Purity: 98.9%

Stocking period: 1 Day

Stock: In Stock

Detail Product Information:
BVT-948 (SPS8I-3) is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) with IC50 of 0.09-1.7 uM. Results show that the effect of BVT948 (BVT.948) is to strengthen the insulin signal and has no effects on the duration of the signal. BVT948 appears to be an effective inhibitor of both protein tyrosine phosphatases (PTP activity and P450 activity)[1]. BVT948 efficiently and selectively suppresses cellular H4 lysine 20 (H4K20me1) at doses lower than 5 μM within 24 h. The cells treated with BVT948 recapitulate cell-cycle-arrest phenotypes similar to what are reported for knocking down SETD8 by RNAi[2]. Treatment of MCF-7 cells with 0.5, 1 or 5 μM of BVT948 for 24 h does not cause any significant changes in cell viability. BVT948 inhibits TPA-induced MMP-9 up-regulation in a dose-dependent manner. Treatment with BVT948 inhibits TPA-stimulated NF-κB binding activity, but not AP-1 binding activity. BVT948 does not affect the MAPK phosphorylation by TPA. Treatment with BVT948 diminishes the TPA-induced cell invasion by 50%[3].Results show that 3 μmol/kg BVT948 (BVT.948) significantly enhances glucose clearance from the blood stream in response to insulin compare with vehicle-treated controls[1].

Name: ShangHai DC Chemicals Co.,Ltd Recommended

Chemsrc Level: Verified

Product #: 14107

Tel: 58447131

Address: Pudong new area Jin Yu road 100#

Area: China(Mainland)

Contact: Tony Lai

Contact Phone #: 13564518121

Email: order@dcchemicals.com

Website: http://www.biomedgen.cn

Foreign Trade % of Salers: 20%

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