3'3'-cGAMP (sodium salt) Price from Supplier Brand ShangHai DC Chemicals Co.,Ltd on Chemsrc.com

Published date: 2024-01-29 15:27:34

CAS number: 849214-04-6

Name: cGAMP

Price:
￥Inquiry/1g

Purity: 98.9%

Stocking period: 1 Day

Stock: In Stock

Detail Product Information:
3’3’-cGAMP Fluorinated (c-[2'FdGMP]-[2'FdAMP]) is a synthetic analog of cyclic guanosine monophosphate- adenosine monophosphate (cyclic GMP-AMP, cGAMP) with a fluorine atom at 2’ position of the nucleosides. 3’3’-cGAMP is a cyclic di-nucleotide produced by bacteria. It is also referred to as "canonical" cGAMP due the presence of the classical 3’-5’ phosphodiester linkages between the guanosine and the adenosine. It has been reported that cGAMP binds STING (stimulator of IFN genes) and subsequently induces TBK1-IRF3-dependent production of IFN-β [1].

The incorporation of fluorine into biologically active molecules is commonly used in medicinal chemistry to improve their metabolic stability or to modulate physicochemical properties such as lipophilicity [2, 3]. Moreover, the introduction of a fluorine atom can change the biological activities of a molecule. Interestingly, when used at low concentrations in various cellular assays, 3’3’-cGAMP Fluorinated induces higher levels of type I IFNs than does cGAMP.

STING ligands such as cGAMP induce type I IFNs and activate interferon stimulated genes (ISG) through IRFs. To facilitate their study, InvivoGen has developed stable reporter cells in two well established immune cell models: THP-1 human monocytes and RAW 264.7 murine macrophages. These cells express a reporter gene (SEAP or Lucia luciferase), under control of an IRF-inducible promoter.

Name: ShangHai DC Chemicals Co.,Ltd Recommended

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Product #: 14107

Tel: 58447131

Address: Pudong new area Jin Yu road 100#

Area: China(Mainland)

Contact: Tony Lai

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Email: order@dcchemicals.com

Website: http://www.biomedgen.cn

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