3-(1-Methyl-1H-pyrrol-2-yl)pyridine

Names

[ CAS No. ]:
487-19-4

[ Name ]:
3-(1-Methyl-1H-pyrrol-2-yl)pyridine

[Synonym ]:
Pyridine, 3-(1-methylpyrrol-2-yl)-
Pyridine, 3- (1-methyl-1H-pyrrol-2-yl)-
Pyridine, 3-(1-methyl-1H-pyrrol-2-yl)-
3-(1-methylpyrrol-2-yl)pyridine
Pyridine, 3- (1-methylpyrrol-2-yl)-

Biological Activity

[Description]:

β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Xiaochen Wei, et al. An Improved Synthesis of β-Nicotyrine from the Dehydrogenation of Nicotine: Comparison of Conventional and Microwave-Assisted Reactions. Synthetic Communications. 2003. Volume 33, Issue 19.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
282.8±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₀N₂

[ Molecular Weight ]:
158.200

[ Flash Point ]:
124.8±20.4 °C

[ Exact Mass ]:
158.084396

[ PSA ]:
17.82000

[ LogP ]:
1.80

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.581

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT6130000

CHEMICAL NAME :: Pyridine, 3-(1-methyl-2-pyrrolyl)-

CAS REGISTRY NUMBER :: 487-19-4

BEILSTEIN REFERENCE NO. :: 0121347

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H10-N2

MOLECULAR WEIGHT :: 158.22

WISWESSER LINE NOTATION :: T6NJ C- BT5NJ A1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4065561

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 575 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4065561

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 191 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 65,366,1982