ML 281
Names
Biological Activity
[Description]:
ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA.target: STK33IC50: 14 nM [1]ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2]
[Related Catalog]:
[References]
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Chemical & Physical Properties
[ Molecular Formula ]:
C22H19N3O2S
[ Molecular Weight ]:
389.47000
[ Exact Mass ]:
389.12000
[ PSA ]:
103.09000
[ LogP ]:
5.10030
[ Storage condition ]:
2-8℃