VU590

Names

[ Name ]:
VU590

[Synonym ]:
VU 590 dihydrochloride

Biological Activity

[Description]:

VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 290 nM (Kir1.1), 8 μM (Kir7.1)[1]

[References]

[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.

[2]. Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₂N₄O₇

[ Molecular Weight ]:
488.53

[ Exact Mass ]:
560.18000

[ PSA ]:
125.81000

[ LogP ]:
5.39680