cholic acid
Names
[ CAS No. ]:
81-25-4
[ Name ]:
cholic acid
[Synonym ]:
Cholalic acid
Cholan-24-oic acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α)- (9CI)
cholic acid
17b-(1-Methyl-3-carboxypropyl)etiocholane-3a,7a,12a-triol
3a,7a,12a-Trihydroxycholanic acid
5β-Cholic acid
3a,7a,12a-Trihydroxy-5b-cholanoic acid
(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
5b-Cholic acid
3a,7a,12a-Trihydroxy-5b-cholanic Acid
3α,7α,12α-trihydroxy-5β-cholan-24-oic acid
CHOLALIN
MFCD00003672
Cholan-24-oic acid, 3,7,12-trihydroxy-, (3α,5β,7α,8ξ,12α,20R)-
EINECS 201-337-8
Cholbam
Cholic&Cyclosphorine
3a,7a,12a-Trihydroxy-b-cholanic acid
3a,7a,12a-Trihydroxy-β-cholanic acid
Cholic acd
5b-Cholanic acid-3a,7a,12a-triol
AHR 3053-13C3
(3α,5β,7α,12α)-3,7,12-Trihydroxycholan-24-oic acid
3a,7a,12a-Trihydroxy-5b-cholan-24-oic Acid
5β-Cholanic acid, 3α,7α,12α-trihydroxy- (7CI)
CHOLATE
Kolbam
UNII-G1JO7801AE
Orphacol
Cholic acid, 5β-
(3a,5b,7a,12a)-3,7,12-Trihydroxycholan-24-oic acid
Cholan-24-oic acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α)-
Cholan-24-oic acid, 3,7,12-trihydroxy-, (3-α,5-β,7-α,12-α)-
(3α,5β,7α,8ξ,12α,20R)-3,7,12-Trihydroxycholan-24-oic acid
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Human Endogenous Metabolite
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
583.9±50.0 °C at 760 mmHg
[ Melting Point ]:
197-202 ºC
[ Molecular Formula ]:
C24H40O5
[ Molecular Weight ]:
408.571
[ Flash Point ]:
321.0±26.6 °C
[ Exact Mass ]:
408.287567
[ PSA ]:
97.99000
[ LogP ]:
2.62
[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C
[ Index of Refraction ]:
1.558
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
0.28 g/L (15 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- FZ9350000
- CHEMICAL NAME :
- Cholic acid
- CAS REGISTRY NUMBER :
- 81-25-4
- BEILSTEIN REFERENCE NO. :
- 2822009
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C24-H40-O5
- MOLECULAR WEIGHT :
- 408.64
- WISWESSER LINE NOTATION :
- L E5 B666TJ A1 DQ E1 FY1&2VQ KQ OQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4950 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 330 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 7560 mg/kg/6W
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 9,387,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84435 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84435 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 511 (estimated) No. of Female Employees: 325 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
FZ9350000
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2942000000
Articles
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The first-known aptamer for the stress biomarker cortisol was selected using a tunable stringency magnetic bead selection strategy. The capture DNA probe immobilized on the beads was systematically le...
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Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli.Antimicrob. Agents Chemother. 51 , 923-9, (2007)
AcrAB-TolC is the major, constitutively expressed tripartite multidrug efflux system in Escherichia coli that recognizes various structurally unrelated molecules, including many antibiotics, dyes, and...