HS-10296
Names
[ CAS No. ]:
1899921-05-1
[ Name ]:
HS-10296
Biological Activity
[Description]:
HS-10296 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity.
[In Vitro]
An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.
Chemical & Physical Properties
[ Molecular Formula ]:
C30H36ClN7O2
[ Molecular Weight ]:
562.11
[ Storage condition ]:
-20℃