3,5-Diiodosalicylic acid

Names

[ CAS No. ]:
133-91-5

[ Name ]:
3,5-Diiodosalicylic acid

[Synonym ]:
3,5-diiodosalicyclic acid
3,5-Diiodo-2-hydroxybenzoic acid
Diiodosalicylic acid
EINECS 205-124-0
3,5-Diiodosalicylic acid
RARECHEM AL BE 0656
Sanoform
2-Hydroxy-3,5-diiodobenzoic acid
2-Hydroxy-3,5-dijod-benzoesaeure
Diosal
3,5-DiiodosalicylicAcid
2-hydroxy-3,5-diiodo-benzoic acid
DISA
3,5-diiodo-salicylicaci
5-Diiodosalicylic acid
MFCD00002444
Salicylic acid,3,5-diiodo
Benzoic acid, 2-hydroxy-3,5-diiodo-

Chemical & Physical Properties

[ Density]:
2.7±0.1 g/cm3

[ Boiling Point ]:
380.8±42.0 °C at 760 mmHg

[ Melting Point ]:
220-230 °C (dec.)(lit.)

[ Molecular Formula ]:
C₇H₄I₂O₃

[ Molecular Weight ]:
389.914

[ Flash Point ]:
184.1±27.9 °C

[ Exact Mass ]:
389.824951

[ PSA ]:
57.53000

[ LogP ]:
4.56

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.784

[ Storage condition ]:
-20°C

[ Water Solubility ]:
0.02 g/100mL (25 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO2800000

CHEMICAL NAME :: Salicylic acid, 3,5-diiodo-

CAS REGISTRY NUMBER :: 133-91-5

BEILSTEIN REFERENCE NO. :: 2615358

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H4-I2-O3

MOLECULAR WEIGHT :: 389.91

WISWESSER LINE NOTATION :: QVR BQ CI EI

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,8,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 19,483,1946

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
VO2800000

[ HS Code ]:
29182990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Solubilization of human sperm antigens.

Arch. Androl. 15(2-3) , 109-16, (1985)

Various methods of solubilization of human sperm antigens were compared by testing the sperm extracts against rabbit antihuman spermatozoa immune serums with double immunodiffusion and rocket immunoel...

Identification of possible calcium dependent antigens in lithium diiodosalicylate extraction of group A, type 12 streptococcal cell membranes.

Res. Commun. Chem. Pathol. Pharmacol. 49(3) , 401-14, (1985)

Group A, type 12 streptococcal cell membranes were extracted by aqueous lithium diiodosalicylate (LIS) and the extract treated with trifluorotrichloroethane (Genetron). An initial component was isolat...

Antigenic differences in human sperm samples related to various morphological abnormalities.

Arch. Androl. 29(2) , 117-26, (1992)

Sperm samples were collected from male partners of fertile and infertile couples having unexplained and male factor infertility and analyzed for morphological abnormalities. After a staining procedure...