1-(2-Pyridinyl)piperazine
Names
[ CAS No. ]:
34803-66-2
[ Name ]:
1-(2-Pyridinyl)piperazine
[Synonym ]:
2-(1-Piperazinyl)pyridine
1-(pyridin-2-yl)piperazine
2-Piperazinopyridine
1-(2-Pyridinyl)piperazine
Piperazine, 1-(2-pyridinyl)-
MFCD00006216
EINECS 252-220-3
2-pyridylpiperazine
1-(2-Pyridyl)Piperazine
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
314.4±22.0 °C at 760 mmHg
[ Melting Point ]:
92-94
[ Molecular Formula ]:
C9H13N3
[ Molecular Weight ]:
163.22
[ Flash Point ]:
143.9±22.3 °C
[ Exact Mass ]:
163.110947
[ PSA ]:
28.16000
[ LogP ]:
0.19
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.547
[ Storage condition ]:
Flammables area
[ Water Solubility ]:
>500 g/L (20 ºC)
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
2735
[ WGK Germany ]:
3
[ Packaging Group ]:
II
[ Hazard Class ]:
8
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Eur. J. Pharmacol. 134(1) , 113-6, (1987)
We investigated in mice the effects of one of the principal metabolites of buspirone and gepirone, 1-(2-pyridinyl)-piperazine (1-PmP), on hypothermia and reduced locomotion induced by clonidine (0.25 ...
6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.Drug Metab. Dispos. 35(8) , 1387-92, (2007)
The pharmacokinetics and in vivo potency of 6-hydroxybuspirone (6-OH-buspirone), a major metabolite of buspirone, were investigated. The plasma clearance (47.3 +/- 3.5 ml/min/kg), volume of distributi...
New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines.Bioorg. Med. Chem. 16 , 8737-44, (2008)
Six new synthetic bile acid derivatives were synthesized and tested in vitro against various human cancer cells (glioblastoma multiforme (GBM), multiple myeloma (KMS-11), and colonic carcinoma (HCT-11...