1-Acetyl-4-(4-hydroxyphenyl)-piperazine

Names

[ Name ]:
1-Acetyl-4-(4-hydroxyphenyl)-piperazine

[Synonym ]:
1-[4-(4-hydroxyphenyl)piperazin-1-yl]ethanone
ethanone, 1-4-(4-hydroxyphenyl)-1-piperazinyl-
1-[4-(4-Hydroxyphenyl)-1-piperazinyl]ethanone
EINECS 267-744-8
1-4-(4-hydroxyphenyl)piperazin-1-ylethanone
MFCD00044905
Ethanone, 1-[4-(4-hydroxyphenyl)-1-piperazinyl]-
1-Acetyl-4-(4-hydroxyphenyl)-piperazine
1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethanon

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
456.5±40.0 °C at 760 mmHg

[ Melting Point ]:
180-185 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₆N₂O₂

[ Molecular Weight ]:
220.268

[ Flash Point ]:
229.9±27.3 °C

[ Exact Mass ]:
220.121185

[ PSA ]:
43.78000

[ LogP ]:
0.19

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.585

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
4.3 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37/39-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

General approach for electrochemical detection of persistent pharmaceutical micropollutants: Application to acetaminophen.

Biosens. Bioelectron. 72 , 205-10, (2015)

We propose in this work a general and versatile methodology for electrochemical monitoring of persistent pharmaceutical micropollutants. The system presented is based on an electroactive and electropo...

New process for synthesis of 1-acetyl-4-(4-hydroxyphenyl) piperazine [J]. Zheng, CZ, et al.

Huaxue Shiji 10 , 27, (2010)

Design of new potent and selective secretory phospholipase A₂ inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives. Meddad-Belhabich N, et al.

Bioorg. Med. Chem. 18(10) , 3588-3600, (2010)