4,4'-Dithiobis[2-Amino-Butanoic-3,3,4,4-D4 acid

Names

[ CAS No. ]:
108641-82-3

[ Name ]:
4,4'-Dithiobis[2-Amino-Butanoic-3,3,4,4-D4 acid

[Synonym ]:
Butanoic-3,3,4,4-d acid, 4,4'-dithiobis[2-amino-
DL-Homocystine-3,3,3`,3`,4,4,4`,4`-d8
4,4'-Disulfanediylbis[2-amino(3,3,4,4-H)butanoic acid]

Biological Activity

[Description]:

DL-Homocystine-3,3,3’,3’,4,4,4’,4’-d8 is the deuterium labeled DL-Homocystine. DL-Homocystine is the double-bonded form of homocysteine and homocysteine is recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Brown AS, et al. Homocysteine and schizophrenia: from prenatal to adult life. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Sep;29(7):1175-80.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
507.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H8D8N2O4S2

[ Molecular Weight ]:
276.403

[ Flash Point ]:
260.8±30.1 °C

[ Exact Mass ]:
276.105347

[ PSA ]:
177.24000

[ LogP ]:
1.03

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds