2-{3-[(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)amino]propyl}-3(2H) -pyridazinone hydrochloride (1:1)
Names
[ CAS No. ]:
110714-10-8
[ Name ]:
2-{3-[(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)amino]propyl}-3(2H) -pyridazinone hydrochloride (1:1)
[Synonym ]:
Guvacolinhydrobromid
methyl 1,2,5,6-tetrahydronicotinate hydrobromide
GYKI-12 743
1,2,5,6-Tetrahydronicotinic Acid Methyl Ester Hydrobromide
norarecoline
1,2,5,6-Tetrahydro-nicotinic Acid Hydrochloride
1,2,5,6-Tetrahydro-pyridin-3-carbonsaeure-methylester,Hydrobromid
1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester hydrobromide
Guvacoline Hydrobromide
Guvacine Methyl Ester Hydrobromide
Chemical & Physical Properties
[ Boiling Point ]:
464.9ºC at 760mmHg
[ Molecular Formula ]:
C16H20ClN3O3
[ Molecular Weight ]:
337.80100
[ Flash Point ]:
235ºC
[ Exact Mass ]:
337.11900
[ PSA ]:
65.38000
[ LogP ]:
2.25590
[ Vapour Pressure ]:
8.02E-09mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UR6340000
- CHEMICAL NAME :
- 3(2H)-Pyridazinone, 2-(3-(((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)amino )propyl)-, monohydrochloride
- CAS REGISTRY NUMBER :
- 110714-10-8
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C16-H19-N3-O3.Cl-H
- MOLECULAR WEIGHT :
- 337.84
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4826845
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 98 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,622,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4826845
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4826845