DHFR-IN-5
Names
[ CAS No. ]:
1142407-81-5
[ Name ]:
DHFR-IN-5
Biological Activity
[Description]:
DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a Ki value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity[1].
[Related Catalog]:
[In Vitro]
DHFR-IN-5 (compound p218) 对 PYR 耐药性 P. falciparum 表现出较高的活性,对野生型 P. falciparum (TM4) 和 4 突变型 P. falciparum (V1/S) 的 IC50 值分别为 4.6, 56 nM[1]。
[In Vivo]
DHFR-IN-5 (compound p218) (30 mg/kg; p.o.) 在大鼠中表现出抗疟疾活性,具有良好的口服生物利用度 (46.3%), 合理的半衰期 (7.3 h)[1]。 Animal Model: Rats[1] Dosage: 30 mg/kg Administration: P.o. Result: Showed good oral bioavailability (46.3%), a reasonable half-life (7.3 h), and minimal distribution into the brain.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C18H24N4O4
[ Molecular Weight ]:
360.41