ERK Inhibitor II (Negative control)

Names

[ CAS No. ]:
1177970-73-8

[ Name ]:
ERK Inhibitor II (Negative control)

[Synonym ]:
HMS3229G08
ERK Inhibitor II,Negative Control

Biological Activity

[Description]:

ERK Inhibitor II (Negative control) is an effective inhibitor of extracellular signal-regulated kinase (ERK). ERK Inhibitor II (Negative control) inhibits the activation of insulin receptor, which can be used in the study of diabetes[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor
Signaling Pathways >> Stem Cell/Wnt >> ERK

[In Vitro]

ERK Inhibitor II (Negative control) ( Irfin1) (10 µM) 抑制 CHO-K1 细胞中胰岛素诱导的胰岛素受体 (IR) 激活[2]。

[References]

[1]. Rezania A, et al. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage. World Intellectual Property Organization. WO2010051223.

[2]. Anastassiadis T, et al. A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor. J Biol Chem. 2013 Sep 27;288(39):28068-77.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H12N6O

[ Molecular Weight ]:
328.32700

[ Exact Mass ]:
328.10700

[ PSA ]:
91.99000

[ LogP ]:
3.04020

Related Compounds