Antimalarial agent 11

Names

[ CAS No. ]:
1214454-56-4

[ Name ]:
Antimalarial agent 11

Biological Activity

[Description]:

Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Iredia D Iyamu, et al. Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity. Bioorg Med Chem. 2022 Mar 1;57:116629.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H25F2NO3

[ Molecular Weight ]:
425.47

Related Compounds