(2H24)Tetradecanedioic acid

Names

[ CAS No. ]:
130348-88-8

[ Name ]:
(2H24)Tetradecanedioic acid

[Synonym ]:
Tetradecanedioic-d acid
(H)Tetradecanedioic acid

Biological Activity

[Description]:

Tetradecanedioic acid-d24 is the deuterium labeled Tetradecanedioic acid[1]. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated drug-drug interactions[2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Santockyte R, et al. LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions. Bioanalysis. 2018 Sep 1;10(18):1473-1485.  

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
434.1±18.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H2D24O4

[ Molecular Weight ]:
282.502

[ Flash Point ]:
230.5±17.7 °C

[ Exact Mass ]:
282.333740

[ PSA ]:
74.60000

[ LogP ]:
3.99

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.475

Related Compounds