(4R)-4-Hydroxy-L-(2,5,5-2H3)proline

Names

[ CAS No. ]:
1356016-86-8

[ Name ]:
(4R)-4-Hydroxy-L-(2,5,5-2H3)proline

[Synonym ]:
(4R)-4-Hydroxy-L-(2,5,5-H)proline
L-Proline-2,5,5-d, 4-hydroxy-, (4R)-

Biological Activity

[Description]:

L-Hydroxyproline-d3 is the deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
355.2±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C5H6D3NO3

[ Molecular Weight ]:
134.148

[ Flash Point ]:
168.6±27.9 °C

[ Exact Mass ]:
134.077072

[ LogP ]:
-1.84

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.540

Related Compounds