LONG R3 IGF-I RECOMBINANT ANALOG

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Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures.

PLoS ONE 9(10) , e110324, (2014)

Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death. Howeve...

Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells.

Cancer Res. 75(8) , 1691-702, (2015)

Breast cancer stem cells (BCSC) are resistant to conventional chemotherapy and radiotherapy, which may destroy tumor masses but not all BCSC that can mediate relapses. In the present study, we showed ...

Inhibition of IGF-I-related intracellular signaling pathways by proinflammatory cytokines in growth plate chondrocytes.

Pediatr. Res. 76(3) , 245-51, (2014)

Children with chronic inflammatory diseases suffer from severe growth failure associated with resistance toward the anabolic action of insulin-like growth factor I (IGF-I). We hypothesized that proinf...

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